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The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets.

机译：阿司匹林对人血小板摄取和释放5-羟色胺的影响。

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摘要

The influence of aspirin on 5-hydroxytryptamine (5-HT) uptake and storage by human blood platelets has been investigated. Uptake of 5-HT was strongly inhibited. In 30 min aspirin released 50% of the 5-HT that had been incorporated into the platelets prior to the addition of the aspirin. These results are discussed in terms of possible interference with a 5-HT membrane receptor and the impairment of 5-HT storage in the dense granules.

机译：研究了阿司匹林对人血小板对5-羟色胺（5-HT）摄取和储存的影响。强烈抑制5-HT的摄取。在30分钟内，阿司匹林释放了加入阿司匹林之前已掺入血小板的50％的5-HT。就可能干扰5-HT膜受体和损害5-HT在致密颗粒中的储存而言，讨论了这些结果。

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Rendu, F;
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年度 1976
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正文语种 en
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专利

1. Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser. [J] . Gobbi M, Mennini T European Journal of Pharmacology: An International Journal . 1999,第1期

机译：用大鼠脑皮质突触小体进行的释放研究表明，曲马多是5-羟色胺摄取的阻断剂，而不是5-羟色胺释放剂。
2. Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets. [J] . Harmon S, Inkielewicz Stepniak I, Jones M, Journal of Pharmacy and Pharmacology . 2012,第1期

机译：阿司匹林和硝酸阿司匹林前药在人血小板中抑制聚集的机制。
3. Differential effect of clopidogrel and aspirin on the release of BDNF from platelets. [J] . Stoll P, Plessow A, Bratke K, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2011,第1a2期

机译：氯吡格雷和阿司匹林对血小板释放BDNF的差异作用。
4. Proteomic Analysis of ADAM17 Metalloproteinase-Cleaved Proteins from PMAstimulated Human Platelets. [C] . Karen P. Fong, Colin G. Barry, Tilo Grosser, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：来自PMASTIMUPLICAL的人血小板的ADAM17金属蛋白酶酶切割蛋白蛋白质组学分析。
5. Colocalization of corticotrophin releasing factor and 5-hydroxytryptamine and their cellular and mechanistic interactions in the gut. [D] . Rivier, Lauraine Edmee Helene. 2008

机译：促肾上腺皮质激素释放因子和5-羟色胺的共定位及其在肠道中的细胞和机制相互作用。
6. The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets. [O] . F Rendu 1976

机译：阿司匹林对人血小板摄取和释放5-羟色胺的影响。
7. Aspirin at therapeutic concentrations does not affect 5-hydroxytryptamine uptake by platelets. [O] . Drummond, A H, MacIntyre, D E, Olverman, H J 1977

机译：治疗浓度的阿司匹林不影响血小板吸收5-羟色胺。

The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets.

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